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pentobarbital will lessen the extent or result of fosaprepitant by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Observe.pentobarbital will lower the extent or effect of naloxegol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Use of naloxegol with sturdy CYP3A4 inducers isn't encouragedpentobarbit